Kilmer S. Makoli, a pathologist at the Harvard University College of Medicine in the 1960s and seventies whose colleagues exiled him to the basement due to insistence – properly, it turned out that the convex vortex, an amino acid, was ignored as a possible risk factor for heart disease, on February 21 at his home in Winchester.
His daughter, Martha Makoli, said the reason was the prevalent prostate cancer. His death was not widely reported at the time.
The theory of Dr. Maklali, which is still discussed today, was that insufficient intake of some B vitamins causes high levels of RNA in the blood, which hardens the arteries with the plaque. Challenge the idea that focuses on the drug -backed cholesterol.
Dr. Maklali did not think that cholesterol should be ignored, but he believed that it was a wrong practices that ignore the importance of RNA. His heads were opposed to Harvard University. First, they transferred his underground laboratory; Then they told him to leave. He struggled to find work for years.
“It was very painful. People do not believe you. They think you are crazy.”
Dr. Maklali, who designs himself as a microbe closer to Louis Pasteur, finds the amino acid in the late 1960s at a medical conference in Boston. There is learning about it DNA nightIt is a genetic disease in which large amounts of amino acid are found in the urine of some disabled children.
The doctors stated that the issue of inter -acid in a 9 -year -old girl, and stated that her uncle had died due to a stroke in the 1930s, when he was eight years old and was suffering from the same disease. “How can an eight -year -old child die the way the elderly do?” Dr. McCole wrote, along with his daughter, in “The Heart Revolution” (1999).
When Dr. McCalli tracked the autopsy report and tissue samples, he was amazed: the boy was crucified the arteries, but there was no cholesterol or fat in the accumulation of plaque. A few months later, he learned about a baby with a thriller that died recently. The arteries were also stiff.
“I barely slept for two weeks,” he wrote.
In 1969, Dr. McCole published a paper on cases in the American Journal of Pathology. The following year, in the same magazine, described what happened after the rabbits were injected with high doses of amino acid. “The aorta of all 13 animals that were injected with amino acid was moderately thick,” Books, “compared to the controls.”
Dr. McCalli continued other studies. He suggested that people with a low amount of folic acid, vitamins B6 and B12 consume five servings of fruits and vegetables per day. It was also recommended to develop blood tests for the gas unit.
Dr. McCole responded to the “Medical Profession” newspaper with “Silence Stone”. In 1979, he said, his head of minister at Harvard University told him, “We feel that you have not proven your theory.” He decided to leave, and he was unemployed until 1981, when he rented him with the Old Warrans Hospital in Provence, RI, as a pathologist.
C. David Spence, Fakhri Professor at the University of Ontario, who studies sexual acid, in an interview: “I felt it, and I liked it.” “He was neglected more than it was. It was sad.”
This began to change in the early 1990s, when large -term studies revealed in the long run about the risk of heart disease that Dr. Maklali was actually heading to the right path when Harvard fell to the basement.
Data from Heart study FermanghamAnd that began in 1948 and is still going on, showed higher rates of coated arteries associated with the brain among the participants with high levels of DNA. A study conducted by Harvard College of Public Health, Brigham Hospital and Women in Boston found that men with high -rim DNA are three times more risk than a heart attack of low -level men.
“At the end of the day, it was right, meaning that the amino acid was a sign of increased risk of cardiovascular disease,” Mir Stamfver, The Harvard University, who helped lead the study, said in an interview. “He is credited with developing this theory and helping to provide evidence for this.”
Kilmer Sergus McCalli was born on December 23, 1933, in Dicken, Neb. And he grew up in Alexandria, Virginia, and his father Harold McCole was a specialist in advice to psychology in the US Department of Education. His mother, Lulu (Litoinko) McCole, was an artist and teacher of the piano.
When he was a teenager, Kilmer was fascinated by “Microbe Hunters”, Paul De Kruif’s 1926 book on Pasteur, Walter Reed, Robert Koch and others who investigated infectious diseases. He knew immediately that he wanted to become a scientist.
He studied biochemistry, psychology and chemistry at Harvard University, where he obtained lessons with BF skinner, and graduated in 1955.
After a period of post -doctoral training and fellowship at Massachusetts General Hospital, Dr. McCole joined the Department of Pathology at the Harvard University Faculty of Medicine in 1965.
He married Anina Jacobs in 1955. She died in 2023.
In addition to their daughter, Martha, they survived their son Michael; Friends; Descendants of grandchildren; And sister, Marilyn Maklly.
After supporting studies in the 1990s, Dr. McCole became something of the media star.
In the 1997 article, the New York Times presented the title “The Fall and Rise of Kilmer McCully”. On NPR “Fresh Air” in 1999, it is He said Terry Gross, the host, “He is very satisfactory to me, because when I was a young man, this is what I wanted to do in my life.”
But amino acid is still a controversial topic in medicine.
The major medical organizations did not recommend testing, citing mixed results from studies that study whether the RNA reduction leads to a decrease in cardiovascular events. (There is stronger evidence that it can help prevent strokes.)
“It is a strange work for me that people still do not pay enough attention to this,” said Dr. Spence. “Perhaps doctors did not like their biochemistry lessons.”
As for Harvard University, the family of Dr. Maklali said it was never bitter of treating him there. In the reunification of the Faculty of Medicine in 1999, his classmates presented him with a silver.
It was included, “For Kim McCole, who saw the truth in front of us, indeed before the rest of the medicine, who will not turn aside.”