IYour doctor told you that a vaccine against dementia was available, will you be interested? According to Ticket April 2 was published in the magazine nature By researchers in the United States and Germany, this question may not be hypothetical anymore.
Varicose-Zustre The virus-which causes fools (chickenpox) in childhood and nature (logical images) after lying in nerve cells and reactivating it later in life-is one virus that have scientists. assumption It can cause dementia, as it affects the nervous system. We have vaccines against both conditions. The chickenpox vaccine protects children with children from the initial viral infection, and the separate virus vaccine prevents the reactivation in previously infected adults (most adults born before smallpox vaccination in a large scale in the late 1990s), which prevents it from causing a painful rash.
The traditional way to see if adult vaccination against this virus can prevent dementia later in life is to have a governed random experience. We used to take a group of adults and divide them randomly into two groups: the “control” group that would not get a vaccine, and the “intervention” group that would get the vaccine. Then, we look forward to knowing if there is a difference in the rates of dementia between the two groups over time. the problem Below, since dementia is a disease of aging, we will have to follow thousands of patients closely, and collect health information over many years – it is not a simple task.
The researchers have not done behind this new study, including Marcus Ann and Pascal Celettzer of Stanford University, none of this. They were smart enough to realize that this experience had already happened – in the way of the transformation – its results remained a mystery awaiting disclosure.
In 2013, the Wales government decided that it would start providing the Al -Nattaqi vaccine to prevent logical images of adults born on September 2, 1933, while those are older than that. no Be qualified. Any person born in September 4, 1933 can get the vaccine, while a person was born just one week ago on August 28, 1933 was unqualified.
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Since the exact week we birth is arbitrary, the Welsh adults born before the cutting were similar to each other except for whether they were qualified to receive the vaccine or not. It was mainly random either to get the logic vaccine or not.
This phenomenon is called from patients who are indiscriminately chosen for the treatment of a natural -scientific experience that occurs “in the wild” without directing any researcher. Natural experiments such as this happen all the time, but they often pass without anyone noticing that the researchers have not discovered from the existing data.
Since it has been approved since the vaccination program started running, researchers can look at the health records of Welsh adults to find out who has developed the dementia and has not done since 2013. What they found are amazing.
Because they were not eligible, almost no one was born before the cutting on the shogy impermissibility. Meanwhile, about half of the two newborns received the vaccine directly, and accordingly, they had lower rates of logical impetigo (because the basic benefit of the vaccine is to reduce the risk of shingles). But it is surprising that those who were eligible to vaccinate also have a much lower rate of diagnosis. The researchers estimated a decrease of approximately 20 % in the diagnosis of dementia between those who were immunized by chance.
As much as this analysis, it does not tell us exactly Why The logic vaccine may have decreased dementia diagnostic rates.
The most obvious interpretation will be that if the reactivation of the virus during the logical duct ring prepares a person to develop dementia, the prevention of activation with the vaccine will reduce the risk of dementia. The researchers found evidence to support this hypothesis. First, those who had more shogy episodes (and thus more viral exchanges) had higher rates of dementia. Secondly, they found that those who received antiviral drugs for logical impermissibility rings – which help to close reactivation – are the lowest rates of dementia compared to those who have not obtained an antiviral drug.
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Another explanation may be that there is something about the body’s response to the same vaccine that protects against dementia. Vaccines work by stimulating the immune system, and the theoretical immune response can affect the brain in a way that reduces the risk of dementia. The researchers found two pieces of evidence that this might be a factor. First, they found that those who recently received the influenza vaccine when they received the logic vaccine, were more protection against the dementia than those who only got the logo vaccine. Second, they decided to consider the differences between men and women, who have been proven to have various immune responses to vaccines. (Women may have Stronger immune responses To vaccinate men). They found that the preventive effect against dementia was much greater among women than men.
Any number of these mechanisms can explain a protective effect of shogy impermissibility against dementia. (One of us, Gina, I explore this deeply in a Suspension Posted in nature Besides the study.) It is clear that there is more research that you can do to understand what is happening here completely, but this study has provided a new road map to direct the investigation in the future.
This progress in our understanding of the domain vaccine, tuberculosis and dementia did not happen without these researchers realized the conditions of a natural experience in Wales and carefully analyzed the data to understand what happened to these patients who received the vaccine. In an era in which data is collected in almost every aspect of our lives, it is awaiting the detection of natural experiences in health care – as long as researchers have the opportunity and resources to find and analyze them.